{"id":5711,"date":"2025-05-21T08:34:59","date_gmt":"2025-05-21T08:34:59","guid":{"rendered":"https:\/\/arthrosamid.be\/patients\/results\/"},"modified":"2025-11-04T09:46:22","modified_gmt":"2025-11-04T09:46:22","slug":"results","status":"publish","type":"page","link":"https:\/\/arthrosamid.be\/en\/patients\/results\/","title":{"rendered":"Results"},"content":{"rendered":"\t\t
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What can you expect from treatment with Arthrosamid?<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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How does Arthrosamid work?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Arthrosamid\u00ae is an injectable hydrogel<\/strong> consisting of 97.5% water and 2.5% crosslinked polyacrylamide<\/strong>. Treatment is via six separate 1 ml injections<\/strong>, where the hydrogel is introduced into the synovial space<\/strong>. This leads to the following physiological changes: <\/p>

\u2714 Tissue growth and thickening<\/strong> – After injection, synovial tissue grows<\/strong> in the open structure of Arthrosamid\u00ae, thickening and strengthening the joint capsule.<\/p>

\u2714 Permanent presence<\/strong> – Arthrosamid\u00ae is not resorbed<\/strong> or degraded<\/strong>, but remains permanently present in the tissue.<\/p>

\u2714 S afety and long-term use<\/strong> – More than 1,800,000 treatments<\/strong> have been performed worldwide with no permanent adverse side effects.<\/p>

\u2714 Knee replacement possible after treatment<\/strong> – In a 10-year retrospective study<\/strong> of 120 patients<\/strong>, 56% did not<\/strong> need a knee replacement after 10 years<\/strong>. For the remaining patients who received a prosthesis, there were no side effects<\/strong> related to the hydrogel. <\/p>

\u2714 Improved tissue elasticity<\/strong> – Clinical studies show a 15% increase in<\/strong> synovial tissue elasticity<\/strong>, normalizing joint function.<\/p>

\u2714 Reduced pain signals<\/strong> – Improved elasticity reduces nocisensory pain perception<\/strong>, leading to reduced pain symptoms<\/strong>.<\/p>

\u2714 Anti-inflammatory effect<\/strong> – Arthrosamid\u00ae thickens synovial tissue and creates a natural barrier<\/strong> to inflammatory cells, reducing inflammatory activity<\/strong>, improving mobility and reducing pain symptoms.<\/p>

\u2714 Healthier synovial fluid<\/strong> – Recent research (2025)<\/strong> shows that patients with a positive response have more hyaluronic acid<\/strong> and less interleukin-6 (IL-6)<\/strong> in their synovial fluid, indicating reduced pro-inflammatory activity<\/strong>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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80% of treated patients experience significant improvement in:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Pain reduction<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Mobility<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Functionality <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Safe and effective treatment<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Improvements are maintained for up to 5 years after initial injection<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Research has demonstrated the effect of Arthrosamid. \nA large proportion of patients benefit from treatment for up to 5 years after a single injection.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Patients under age 70 have a positive result in more cases than patients over age 70.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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How safe is Arthrosamid\u00ae?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Arthrosamid\u00ae intra-articular (IA) polyacrylamide gel (iPAAG) is safe for its intended use in the treatment of pain symptoms in knee osteoarthritis. The most common adverse events (side effects) in clinical trials were injection-related mild to moderate pain and or mild swelling during the first weeks after injection. <\/p>\n

More than 1,800,000 treatments have now been performed with this hydrogel over the past 25 years with no known negative side effects that can be related to the hydrogel.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Long-term safety of iPAAG in knee osteoarthritis<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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An observational long-term study examined the safety of intra-articular 2.5% polyacrylamide hydrogel (iPAAG) in patients with knee osteoarthritis (OA). The study followed 61 patients (89 knees)<\/strong> for 7 to 14 years<\/strong> (mean 9.92 years). The mean age at injection was 64 years. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Key findings:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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No significant adverse events<\/strong> were reported related to iPAAG, including no allergies, infections or systemic effects.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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43.8% of treated knees<\/strong> eventually underwent knee replacement, on average after 3.4 years.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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56.2% of knees<\/strong> did not<\/strong> need a prosthesis<\/strong> even after 10 years, after only one treatment.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Surgical complications<\/strong> in subsequent knee replacements were minimal and not related to iPAAG.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Conclusion<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Results confirm a favorable long-term safety profile<\/strong>. iPAAG appears to be a reliable, non-surgical treatment option for knee osteoarthritis, with potential to delay knee replacements for a long time. <\/p>

<\/p>

For further results, please refer to the clinical data where all literature is listed with a link\/reference to the article.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

What can you expect from treatment with Arthrosamid? How does Arthrosamid work? Arthrosamid\u00ae is an injectable hydrogel consisting of 97.5% water and 2.5% crosslinked polyacrylamide. Treatment is via six separate 1 ml injections, where the hydrogel is introduced into the synovial space. This leads to the following physiological changes: \u2714 Tissue growth and thickening – […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":5660,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"iawp_total_views":34,"footnotes":""},"class_list":["post-5711","page","type-page","status-publish","hentry"],"yoast_head":"\nResults - Behandeling knieartrose ARTHROSAMID Injectie<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/arthrosamid.be\/en\/patients\/results\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Results - Behandeling knieartrose ARTHROSAMID Injectie\" \/>\n<meta property=\"og:description\" content=\"What can you expect from treatment with Arthrosamid? How does Arthrosamid work? Arthrosamid\u00ae is an injectable hydrogel consisting of 97.5% water and 2.5% crosslinked polyacrylamide. Treatment is via six separate 1 ml injections, where the hydrogel is introduced into the synovial space. This leads to the following physiological changes: \u2714 Tissue growth and thickening – […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/arthrosamid.be\/en\/patients\/results\/\" \/>\n<meta property=\"og:site_name\" content=\"Behandeling knieartrose ARTHROSAMID Injectie\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-04T09:46:22+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/arthrosamid.be\\\/en\\\/patients\\\/results\\\/\",\"url\":\"https:\\\/\\\/arthrosamid.be\\\/en\\\/patients\\\/results\\\/\",\"name\":\"Results - Behandeling knieartrose ARTHROSAMID Injectie\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/arthrosamid.be\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/arthrosamid.be\\\/en\\\/patients\\\/results\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/arthrosamid.be\\\/en\\\/patients\\\/results\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/arthrosamid.be\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/grouped-studies-5yrs-10-25-outline_2025-10-09-125910_chro.svg\",\"datePublished\":\"2025-05-21T08:34:59+00:00\",\"dateModified\":\"2025-11-04T09:46:22+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/arthrosamid.be\\\/en\\\/patients\\\/results\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/arthrosamid.be\\\/en\\\/patients\\\/results\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/arthrosamid.be\\\/en\\\/patients\\\/results\\\/#primaryimage\",\"url\":\"https:\\\/\\\/arthrosamid.be\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/grouped-studies-5yrs-10-25-outline_2025-10-09-125910_chro.svg\",\"contentUrl\":\"https:\\\/\\\/arthrosamid.be\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/grouped-studies-5yrs-10-25-outline_2025-10-09-125910_chro.svg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/arthrosamid.be\\\/en\\\/patients\\\/results\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/arthrosamid.be\\\/en\\\/patients\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Patients\",\"item\":\"https:\\\/\\\/arthrosamid.be\\\/en\\\/patients\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Results\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/arthrosamid.be\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/arthrosamid.be\\\/en\\\/\",\"name\":\"Behandeling knieartrose ARTHROSAMID Injectie\",\"description\":\"Een veilige behandeling van knieartrose zonder operatie\",\"publisher\":{\"@id\":\"https:\\\/\\\/arthrosamid.be\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/arthrosamid.be\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/arthrosamid.be\\\/en\\\/#organization\",\"name\":\"Arthrosamid powered by Supportho Medical\",\"url\":\"https:\\\/\\\/arthrosamid.be\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/arthrosamid.be\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/arthrosamid.be\\\/wp-content\\\/uploads\\\/2025\\\/05\\\/Arthrosamid-logo.png\",\"contentUrl\":\"https:\\\/\\\/arthrosamid.be\\\/wp-content\\\/uploads\\\/2025\\\/05\\\/Arthrosamid-logo.png\",\"width\":517,\"height\":162,\"caption\":\"Arthrosamid powered by Supportho Medical\"},\"image\":{\"@id\":\"https:\\\/\\\/arthrosamid.be\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Results - Behandeling knieartrose ARTHROSAMID Injectie","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/arthrosamid.be\/en\/patients\/results\/","og_locale":"en_US","og_type":"article","og_title":"Results - Behandeling knieartrose ARTHROSAMID Injectie","og_description":"What can you expect from treatment with Arthrosamid? How does Arthrosamid work? Arthrosamid\u00ae is an injectable hydrogel consisting of 97.5% water and 2.5% crosslinked polyacrylamide. Treatment is via six separate 1 ml injections, where the hydrogel is introduced into the synovial space. 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